UPLC® System was used, including the Altus A-30 Solvent/ Sample Module, integrated vacuum degasser, A-30 Column Heater, and Altus A-30 UV detector (PerkinElmer, Shelton, CT, USA). All instrument control, analysis, and data processing was performed using the Waters ® Empower 3 Chromatography Data Software (CDS) platform. Method Parameters