At the times of 0, 5, 10, 15, 30 and 60 min, a 1 mL sample was taken, filtered with a 0.45 µm PTFE filter, transferred to a chromatography vial and analyzed by the HPLC method detailed in Section 2.3. In the case of the commercial paracetamol tablet, the assay was stopped at 30 min because of its early complete dissolution.